| 5.8S ribosomal RNA | |
|---|---|
| Predicted secondary structure and sequence conservation of 5.8S ribosomal RNA | |
| Identifiers | |
| Symbol | 5_8S_rRNA |
| Rfam | RF00002 |
| Other data | |
| RNA type | Gene; rRNA |
| Domain(s) | Eukaryota; Archaea |
| GO | 0003735 0005840 |
| SO | 0000375 |
In molecular biology the 5.8S ribosomal RNA (5.8S rRNA) is a non-coding RNA component of the large subunit of the eukaryotic ribosome and so plays an important role in protein translation. It is transcribed by RNA polymerase I as part of the 45S precursor that also contains 18S and 28S rRNA. Its function is thought to be in 5.8S rRNA ribosome translocation.[1] It is also known to form covalent linkage to the p53 tumour suppressor protein.[2] 5.8S rRNA is also found in archaea.
5.8S rRNA can be used as a reference gene for miRNA detection.[3]
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